منابع مشابه
Gene profiling of polycystic kidneys.
BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...
متن کاملErythropoietin in polycystic kidneys.
Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29 +/- 7 and 16 +/- 1.5 mU/ml and hemoglobin concentrations were 11.0 +/- 0.6 and 12.7 +/- 1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtaine...
متن کاملGene Expression Profiling of Human Kidneys Undergoing Laparoscopic Donor Nephrectomy
BACKGROUND AND OBJECTIVES The objective was to compare gene expression profiles of 6 kidneys from open donor nephrectomy with 6 kidneys removed after laparoscopic donor nephrectomy and several hours of carbon dioxide pneumoperitoneum with DNA microarrays and identify small-molecule drugs. METHODS The gene expression profile GSE3297 was downloaded from the Gene Expression Omnibus database, and...
متن کاملBicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.
Genetic defects in autosomal-dominant polycystic kidney disease (ADPKD) promote cystic growth of renal tubules, at least in part by stimulating the accumulation of cAMP. How renal cAMP levels are regulated is incompletely understood. We show that cAMP and the expression of its synthetic enzyme adenylate cyclase-6 (AC6) are up-regulated in cystic kidneys of Bicc1(-)(/-) knockout mice. Bicc1, a p...
متن کاملClinical aspects of polycystic disease of the kidneys.
Seventy-eight patients were treated for polycystic disease of the kidneys. An analysis of the interval between the onset of symptoms and end-stage renal failure made it possible to give and accurate prognosis in individual cases. Pregnancy and urinary infection did not appear to accelerate deterioration of renal function, but Rovsing' operation precipitated renal failure in some cases. Forty-tw...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2006
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfl071